Identification of atypical (non-AT1, non-AT2) angiotensin binding sites with high affinity for angiotensin I on IEC-18 rat intestinal epithelial cells.

Abstract

Specific high-affinity (Kd = 3.4 nM) binding sites for 125I-labelled angiotensin I ([125I]Ang I) were identified on an epithelial cell line (IEC-18) derived from the rat small intestine. The sites, which also have high affinity for Ang II, are insensitive to both AT1- and AT2-specific angiotensin receptor antagonists. The rank order of potency with which various angiotensin peptides inhibited [125I]Ang I binding to the cells (Ang I > or = Ang II > Ang(1-7) > [Sar1,Ile8]-Ang II > Ang(3-8) > Ang III) also distinguishes these sites from AT1 and AT2 angiotensin receptors.

Statistics

050100150'99'01'03'05'07'09'11'13'15'17
Citations per Year

144 Citations

Semantic Scholar estimates that this publication has 144 citations based on the available data.

See our FAQ for additional information.

Cite this paper

@article{Smith1995IdentificationOA, title={Identification of atypical (non-AT1, non-AT2) angiotensin binding sites with high affinity for angiotensin I on IEC-18 rat intestinal epithelial cells.}, author={R Davis Smith}, journal={FEBS letters}, year={1995}, volume={373 3}, pages={199-202} }