Identification of 2,3-diaryl-pyrazolo[1,5-b]pyridazines as potent and selective cyclooxygenase-2 inhibitors.

@article{Beswick2004IdentificationO2,
  title={Identification of 2,3-diaryl-pyrazolo[1,5-b]pyridazines as potent and selective cyclooxygenase-2 inhibitors.},
  author={Paul J Beswick and Sharon Bingham and C. Bountra and Terry Brown and Kerry Browning and Ian B Campbell and Iain Chessell and Nick Clayton and Sue D Collins and John A Corfield and Stephen B Guntrip and Claudine G Haslam and Paul F Lambeth and Fiona S. Lucas and N Binoy Mathews and Graham Murkit and Alan S. R. Naylor and Neil A Pegg and Elizabeth A Pickup and Hazel Player and Helen S Price and Alexander Stevens and Sharon C Stratton and Joanne O Wiseman},
  journal={Bioorganic & medicinal chemistry letters},
  year={2004},
  volume={14 21},
  pages={5445-8}
}
GW406381 (8), currently undergoing clinical evaluation for the treatment of inflammatory pain is a member of a novel series of 2,3-diaryl-pyrazolo[1,5-b]pyridazine based cyclooxygenase-2 (COX-2) inhibitors, which have been shown to be highly potent and selective. Several examples of the series, in addition to possessing favourable pharmacokinetic profiles and analgesic activity in vivo, have also demonstrated relatively high brain penetration in the rat compared with the clinically available… CONTINUE READING

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