Identification of arsenite-and arsenic diglutathione-binding proteins in human hepatocarcinoma cells.

@article{Mizumura2010IdentificationOA,
  title={Identification of arsenite-and arsenic diglutathione-binding proteins in human hepatocarcinoma cells.},
  author={Ayano Mizumura and Takayuki Watanabe and Yayoi Kobayashi and Seishiro Hirano},
  journal={Toxicology and applied pharmacology},
  year={2010},
  volume={242 2},
  pages={119-25}
}
It is generally accepted that trivalent arsenicals are more toxic than the corresponding pentavalent arsenicals, since trivalent arsenicals bind the thiol groups of biomolecules, leading to a deterioration in cellular functions. In the present study, we prepared three different arsenic-bound sepharoses and investigated the binding of hepatic cytosolic proteins to pentavalent, trivalent, and glutathione-conjugated trivalent arsenicals. SDS-PAGE showed no proteins bound to pentavalent arsenic… CONTINUE READING

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