Identification of antischistosomal leads by evaluating bridged 1,2,4,5-tetraoxanes, alphaperoxides, and tricyclic monoperoxides.

Abstract

Although antischistosomal properties of peroxides were studied in recent years, systematic structure-activity relationships have not been conducted. We evaluated the antischistosomal potential of 64 peroxides belonging to bridged 1,2,4,5-tetraoxanes, alphaperoxides, and tricyclic monoperoxides. Thirty-nine compounds presented IC₅₀ values <15 μM on newly… (More)
DOI: 10.1021/jm3009184

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@article{Ingram2012IdentificationOA, title={Identification of antischistosomal leads by evaluating bridged 1,2,4,5-tetraoxanes, alphaperoxides, and tricyclic monoperoxides.}, author={Katrin J Ingram and Ivan A Yaremenko and Igor B Krylov and Lorenz Hofer and Alexander O Terent'ev and Jennifer Keiser}, journal={Journal of medicinal chemistry}, year={2012}, volume={55 20}, pages={8700-11} }