Identification of anhydroecgonine methyl ester N-oxide, a new metabolite of anhydroecgonine methyl ester, using electrospray mass spectrometry.

@article{Fandio2002IdentificationOA,
  title={Identification of anhydroecgonine methyl ester N-oxide, a new metabolite of anhydroecgonine methyl ester, using electrospray mass spectrometry.},
  author={Anabel S Fandi{\~n}o and M. Karas and Stefan W Toennes and Gerold F. Kauert},
  journal={Journal of mass spectrometry : JMS},
  year={2002},
  volume={37 5},
  pages={525-32}
}
Cocaine is transformed into hepatotoxic metabolites through oxidative pathways. For anhydroecgonine methyl ester (AEME), the main constituent in crack smoke, the oxidative metabolism has not been studied. Therefore, incubation of AEME with rat liver microsomes was performed and a metabolite of AEME, anhydroecgonine methyl ester N-oxide (AEMENO), was identified. The chemical structure of this new metabolite was confirmed by synthesis and by comparative interpretation of electrospray multiple… CONTINUE READING

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