Identification of androgen response elements in the enhancer I of hepatitis B virus: a mechanism for sex disparity in chronic hepatitis B.

@article{Wang2009IdentificationOA,
  title={Identification of androgen response elements in the enhancer I of hepatitis B virus: a mechanism for sex disparity in chronic hepatitis B.},
  author={Sheng-han Wang and Shiou-Hwei Yeh and Wei-Hsiang Lin and Hurng-Yi Wang and Derhan Chen and Pei-Jer Chen},
  journal={Hepatology},
  year={2009},
  volume={50 5},
  pages={
          1392-402
        }
}
UNLABELLED Hepatitis B virus (HBV)-related hepatocellular carcinoma (HCC) occurs more often in men than in women. Male HBV carriers usually have higher viral loads, which is a well-known risk factor for HCC. Whether and how the male androgen axis regulates HBV transcription and replication is investigated here. We used HBV transgenic mice to evaluate any sex disparity of serum hepatitis B surface antigen and HBV titers as well as the castration effect on this disparity. Compared to females, HBV… CONTINUE READING
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