Identification of androgen-inducible TGF-beta1 derived from dermal papilla cells as a key mediator in androgenetic alopecia.

  title={Identification of androgen-inducible TGF-beta1 derived from dermal papilla cells as a key mediator in androgenetic alopecia.},
  author={Shigeki Inui and Yoko Fukuzato and Takeshi Nakajima and Kunihiko Yoshikawa and Satoshi Itami},
  journal={The journal of investigative dermatology. Symposium proceedings},
  volume={8 1},
  • S. InuiY. Fukuzato S. Itami
  • Published 1 June 2003
  • Biology
  • The journal of investigative dermatology. Symposium proceedings
We attempted to establish a coculture model of human dermal papilla cells (DPCs) from androgenetic alopecia (AGA) and keratinocytes (KCs) to study the pathomechanism of AGA. Since expression of mRNA for the androgen receptor (AR) decreased during subcultivation of DPCs in vitro, we transiently transfected the AR expression vector into the DPCs and cocultured them with KCs. In this coculture, androgen inhibited the growth of KCs by 50%, indicating that the DPCs produce diffusible growth… 

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