Identification of anaplastic lymphoma kinase fusions in renal cancer: large-scale immunohistochemical screening by the intercalated antibody-enhanced polymer method.

@article{Sugawara2012IdentificationOA,
  title={Identification of anaplastic lymphoma kinase fusions in renal cancer: large-scale immunohistochemical screening by the intercalated antibody-enhanced polymer method.},
  author={Emiko Sugawara and Yuki Togashi and Naoto Kuroda and Seiji Sakata and Satoko Hatano and Reimi Asaka and Takeshi Yuasa and Junji Yonese and Masanobu Kitagawa and Hiroyuki Mano and Yuichi Ishikawa and Kengo Takeuchi},
  journal={Cancer},
  year={2012},
  volume={118 18},
  pages={4427-36}
}
BACKGROUND Several promising molecular-targeted drugs are used for advanced renal cancers. However, complete remission is rarely achieved, because none of the drugs targets a key molecule that is specific to the cancer, or is associated with "oncogene addiction" (dependence on one or a few oncogenes for cell survival) of renal cancer. Recently, an anaplastic lymphoma kinase (ALK) fusion, vinculin-ALK, has been reported in pediatric renal cell carcinoma (RCC) cases who have a history of sickle… CONTINUE READING
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and 3 cases treated with an inhibitor for ALK kinase activity

  • A Yoshida, K Tsuta, H Nakamura
  • 2012

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