Identification of an orphan response regulator required for the virulence of Francisella spp. and transcription of pathogenicity island genes.

@article{Mohapatra2007IdentificationOA,
  title={Identification of an orphan response regulator required for the virulence of Francisella spp. and transcription of pathogenicity island genes.},
  author={Nrusingh Prasad Mohapatra and Shilpa Soni and Brian L. Bell and Richard Warren and Robert K Ernst and Artur Muszyński and Russell W Carlson and John S Gunn},
  journal={Infection and immunity},
  year={2007},
  volume={75 7},
  pages={
          3305-14
        }
}
Francisella tularensis is a category A agent of biowarfare/biodefense. Little is known about the regulation of virulence gene expression in Francisella spp. Comparatively few regulatory factors exist in Francisella, including those belonging to two-component systems (TCS). However, orphan members of typical TCS can be identified. To determine if orphan TCS members affect Francisella gene expression, a gene encoding a product with high similarity to the Salmonella PmrA response regulator… CONTINUE READING
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