Identification of an internal cis-element essential for the human L1 transcription and a nuclear factor(s) binding to the element.

@article{Minakami1992IdentificationOA,
  title={Identification of an internal cis-element essential for the human L1 transcription and a nuclear factor(s) binding to the element.},
  author={R. Minakami and K. Kurose and K. Etoh and Y. Furuhata and M. Hattori and Y. Sakaki},
  journal={Nucleic acids research},
  year={1992},
  volume={20 12},
  pages={
          3139-45
        }
}
L1 (LINE-1) is a long interspersed repetitive sequence derived from a retrotransposon. Transfection studies using the CAT gene as a reporter demonstrated that the first 155bp in the human L1 sequence contains an element(s) responsible for the promoter activity in HeLa cells. The transcription was shown to initiate at the first nucleotide of the L1 sequence in the transgene. Three prominent nuclear protein binding sites were found in the 5' region of the L1 sequence by DNaseI footprint analysis… Expand
Sense transcripts originated from an internal part of the human retrotransposon LINE-1 5' UTR.
Key role of the internal 5′-UTR segment in the transcription activity of the human L1 retrotransposon
Transcriptional regulation of the human LINE-1 retrotransposon L1.2B
An important role for RUNX3 in human L1 transcription and retrotransposition.
...
1
2
3
4
5
...