Identification of an internal cis-element essential for the human L1 transcription and a nuclear factor(s) binding to the element.

  title={Identification of an internal cis-element essential for the human L1 transcription and a nuclear factor(s) binding to the element.},
  author={Reiko Minakami and Kyoko Kurose and Ken-ichiro Etoh and Y Furuhata and Masahira Hattori and Yoshiyuki Sakaki},
  journal={Nucleic acids research},
  volume={20 12},
L1 (LINE-1) is a long interspersed repetitive sequence derived from a retrotransposon. Transfection studies using the CAT gene as a reporter demonstrated that the first 155bp in the human L1 sequence contains an element(s) responsible for the promoter activity in HeLa cells. The transcription was shown to initiate at the first nucleotide of the L1 sequence in the transgene. Three prominent nuclear protein binding sites were found in the 5' region of the L1 sequence by DNaseI footprint analysis… 

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Transcriptional regulation of the human LINE-1 retrotransposon L1.2B

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RNA expression from a site-specific non-LTR retrotransposon microinjected into Xenopus oocytes

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An important role for RUNX3 in human L1 transcription and retrotransposition.

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Environmental factors affecting transcription of the human L1 retrotransposon. I. Steroid hormone-like agents.

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  • Quant. Biol
  • 1986