Identification of an integral plasma membrane pool of protein kinase C in mammalian tissues and cells.

@article{Zhu2005IdentificationOA,
  title={Identification of an integral plasma membrane pool of protein kinase C in mammalian tissues and cells.},
  author={Yiming Zhu and Wee Guan Lim and Bee Jen Tan and Tian Seng Teo and Wei Duan},
  journal={Cellular signalling},
  year={2005},
  volume={17 9},
  pages={1125-36}
}
Protein kinase C (PKC) is a family of serine/threonine protein kinases that are pivotal in cellular regulation. Since its discovery in 1977, PKCs have been known as cytosolic and peripheral membrane proteins. However, there are reports that PKC can insert into phospholipids vesicles in vitro. Given the intimate relationship between the plasma membrane and the activation of PKC, it is important to determine whether such "membrane-inserted" form of PKC exists in mammalian cells or tissues. Here… CONTINUE READING
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