Identification of an inhibitory Zn2+ binding site on the human glycine receptor alpha1 subunit.

@article{Harvey1999IdentificationOA,
  title={Identification of an inhibitory Zn2+ binding site on the human glycine receptor alpha1 subunit.},
  author={Robert J Harvey and P. K. Thomas and Colin H. James and Andrew F Wilderspin and Trevor G Smart},
  journal={The Journal of physiology},
  year={1999},
  volume={520 Pt 1},
  pages={53-64}
}
1. Whole-cell glycine-activated currents were recorded from human embryonic kidney (HEK) cells expressing wild-type and mutant recombinant homomeric glycine receptors (GlyRs) to locate the inhibitory binding site for Zn2+ ions on the human alpha1 subunit. 2. Glycine-activated currents were potentiated by low concentrations of Zn2+ (<10 microM) and inhibited by higher concentrations (>100 microM) on wild-type alpha1 subunit GlyRs. 3. Lowering the external pH from 7.4 to 5.4 inhibited the glycine… CONTINUE READING

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