Identification of an inducible endothelial-leukocyte adhesion molecule.

  title={Identification of an inducible endothelial-leukocyte adhesion molecule.},
  author={Michael P. Bevilacqua and Jordan S Pober and Donna L. Mendrick and Ramzi S. Cotran and Michael A. Gimbrone},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  volume={84 24},
The accumulation of blood leukocytes at sites of inflammation depends upon their localized adhesion to the vascular lining. We have investigated the hypothesis that this adhesive interaction involves inducible endothelial cell-surface structures that can bind leukocytes. Certain inflammatory/immune cytokines, namely interleukin 1, tumor necrosis factor, and lymphotoxin, as well as bacterial endotoxin, act on cultured human endothelial cells (HEC) in a time- and protein-synthesis-dependent… CONTINUE READING
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