Identification of an expressed truncated form of CD200, CD200tr, which is a physiologic antagonist of CD200-induced suppression.

@article{Chen2008IdentificationOA,
  title={Identification of an expressed truncated form of CD200, CD200tr, which is a physiologic antagonist of CD200-induced suppression.},
  author={Zhiqi Chen and D K Chen and Yu Kai and Ismat A Khatri and Brent Lamptey and Reginald M Gorczynski},
  journal={Transplantation},
  year={2008},
  volume={86 8},
  pages={1116-24}
}
BACKGROUND Earlier studies have indicated that cell surface expressed CD200, or a soluble form of this molecule, can induce immunosuppression in a number of biological systems, and promote increased graft acceptance, after binding to receptors (CD200Rs). Many groups have reported that the NH2-terminal region of CD200 is crucial for interaction with CD200R. METHODS A truncated form of the full-length, immunosuppression-inducing molecule, CD200, representing translation of an mRNA splice… CONTINUE READING
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