Identification of an evolutionarily conserved superfamily of DOCK180-related proteins with guanine nucleotide exchange activity.

@article{Ct2002IdentificationOA,
  title={Identification of an evolutionarily conserved superfamily of DOCK180-related proteins with guanine nucleotide exchange activity.},
  author={J C{\^o}t{\'e} and Kristiina Vuori},
  journal={Journal of cell science},
  year={2002},
  volume={115 Pt 24},
  pages={4901-13}
}
Mammalian DOCK180 protein and its orthologues Myoblast City (MBC) and CED-5 in Drosophila and Caenorhabditis elegans, respectively, function as critical regulators of the small GTPase Rac during several fundamentally important biological processes, such as cell motility and phagocytosis. The mechanism by which DOCK180 and its orthologues regulate Rac has remained elusive. We report here the identification of a domain within DOCK180 named DHR-2 (Dock Homology Region-2) that specifically binds to… CONTINUE READING
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