Identification of an enhancer involved in the melanoma-specific expression of the tumor antigen melanotransferrin gene.

@article{Duchange1992IdentificationOA,
  title={Identification of an enhancer involved in the melanoma-specific expression of the tumor antigen melanotransferrin gene.},
  author={Nathalie Duchange and Alejandro Molina Ochoa and Gregory D. Plowman and A Roz{\'e} and Mahmoud Amdjadi and Mario M. Zakin},
  journal={Nucleic acids research},
  year={1992},
  volume={20 11},
  pages={
          2853-9
        }
}
Melanotransferrin (MTf) is a tumor associated antigen found in abundance on the surface of melanoma cells. It is a transferrin-like protein found in low amount in most adult tissues and whose gene is reminiscent of house-keeping genes. With the goal of understanding the regulatory mechanisms which might explain the enhancement of expression in tumor cells, we report here the characterization of a regulatory element located 2 kbp upstream from the promoter and whose deletion specifically impairs… CONTINUE READING
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