Identification of an encephalitogenic determinant of myelin proteolipid protein for SJL mice.

@article{Tuohy1989IdentificationOA,
  title={Identification of an encephalitogenic determinant of myelin proteolipid protein for SJL mice.},
  author={Vincent K. Tuohy and Zichun J Lu and Raymond A Sobel and Richard A. Laursen and Marjorie B. Lees},
  journal={Journal of immunology},
  year={1989},
  volume={142 5},
  pages={1523-7}
}
PLP is the major protein constituent of central nervous system myelin. We have previously shown that SJL/J (H-2s) mice develop an acute form of EAE after immunization with PLP. The purpose of the present study was to identify an encephalitogenic determinant of PLP for SJL mice. We immunized SJL/J mice with a synthetic peptide identical to residues 130-147 QAHSLERVCHCLGKWLGH of murine PLP, a sequence having an amphipathic alpha-helical conformation. Although it did not induce disease, an… CONTINUE READING
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