Identification of an elaborate complex mediating postsynaptic inhibition

@article{Uezu2016IdentificationOA,
  title={Identification of an elaborate complex mediating postsynaptic inhibition},
  author={Akiyoshi Uezu and Daniel J. Kanak and Tyler W. A. Bradshaw and Erik J. Soderblom and Christina M. Catavero and Alain C. Burette and Richard J. Weinberg and Scott H Soderling},
  journal={Science},
  year={2016},
  volume={353},
  pages={1123-1129}
}
Inhibitory synapses dampen neuronal activity through postsynaptic hyperpolarization. The composition of the inhibitory postsynapse and the mechanistic basis of its regulation, however, remain poorly understood. We used an in vivo chemico-genetic proximity-labeling approach to discover inhibitory postsynaptic proteins. Quantitative mass spectrometry not only recapitulated known inhibitory postsynaptic proteins but also revealed a large network of new proteins, many of which are either implicated… CONTINUE READING
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sciencemag.org SCIENCE RESEARCH | RESEARCH ARTICLES

  • H. Takahashi et al, Nat
  • 2016
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