Identification of an effector specificity subregion within the aromatic-responsive regulators DmpR and XylR by DNA shuffling.

@article{Skrfstad2000IdentificationOA,
  title={Identification of an effector specificity subregion within the aromatic-responsive regulators DmpR and XylR by DNA shuffling.},
  author={Eleonore Sk{\"a}rfstad and E A O'neill and J. Gonz{\'a}lez Garmendia and Victoria Shingler},
  journal={Journal of bacteriology},
  year={2000},
  volume={182 11},
  pages={3008-16}
}
The Pseudomonas derived sigma(54)-dependent regulators DmpR and XylR control the expression of genes involved in catabolism of aromatic compounds. Binding to distinct, nonoverlapping groups of aromatic effectors controls the activities of these transcriptional activators. Previous work has derived a common mechanistic model for these two regulators in which effector binding by the N-terminal 210 residues (the A-domain) of the protein relieves repression of an intrinsic ATPase activity essential… CONTINUE READING

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