Identification of an autocrine chondrocyte colony-stimulating factor: chondromodulin-I stimulates the colony formation of growth plate chondrocytes in agarose culture.

@article{Inoue1997IdentificationOA,
  title={Identification of an autocrine chondrocyte colony-stimulating factor: chondromodulin-I stimulates the colony formation of growth plate chondrocytes in agarose culture.},
  author={Hirokazu Inoue and Jun Kondo and T. Koike and Chisa Shukunami and Yuji Hiraki},
  journal={Biochemical and biophysical research communications},
  year={1997},
  volume={241 2},
  pages={395-400}
}
Chondrocytes are unique among non-transformed cells in that they are capable of anchorage-independent growth in soft agar. Fibroblast growth factor (FGF) is known as a potent colony-stimulating factor for chondrocytes. However, cartilage extracts contain a potent colony-stimulating activity which is not explicable only by contaminating FGF. We previously isolated the 25 kDa cartilage-specific glycoprotein chondromodulin-I (ChM-I) which stimulates the growth of chondrocytes. In the present study… CONTINUE READING

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