Identification of an autoantigen on the surface of apoptotic human T cells as a new protein interacting with inflammatory group IIA phospholipase A2.

@article{Boilard2003IdentificationOA,
  title={Identification of an autoantigen on the surface of apoptotic human T cells as a new protein interacting with inflammatory group IIA phospholipase A2.},
  author={Eric Boilard and Sylvain G. Bourgoin and Chantale Bernatchez and Marc E. Surette},
  journal={Blood},
  year={2003},
  volume={102 8},
  pages={
          2901-9
        }
}
One of the most studied secreted phospholipases A2 (sPLA2), the group IIA sPLA2, is found at high levels in inflammatory fluids of patients with autoimmune diseases. A characteristic of group IIA sPLA2 is its preference for negatively charged phospholipids, which become exposed on the extracellular leaflet of apoptotic cell membranes. We recently showed that low molecular weight heparan sulfate proteoglycans (HSPGs) and uncharacterized detergent-insoluble binding site(s) contribute to the… CONTINUE READING
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