Identification of an astacin matrix metalloprotease as target gene for Hydra foot activator peptides

@article{Kumpfmller1999IdentificationOA,
  title={Identification of an astacin matrix metalloprotease as target gene for Hydra foot activator peptides},
  author={Gaby Kumpfm{\"u}ller and Vassili Rybakine and Toshio Takahashi and Toshitaka Fujisawa and Thomas C. G. Bosch},
  journal={Development Genes and Evolution},
  year={1999},
  volume={209},
  pages={601-607}
}
Abstract Peptides serve as important signaling molecules in development and differentiation in Hydra. Two peptides, Hym-346 and pedibin, have recently been identified to act as morphogenetic signals for foot differentiation. In screening for target genes for Hym-346 we have isolated an astacin matrix metalloprotease, termed foot activator responsive matrix metalloprotease (Farm1). Farm1 is normally expressed in epithelial cells of the gastric region and absent in apical and basal tissue… 
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Expression of meprins in health and disease.
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References

SHOWING 1-10 OF 32 REFERENCES
Systematic isolation of peptide signal molecules regulating development in hydra: LWamide and PW families.
TLDR
The evidence obtained so far suggests that hydra contains a large number of peptide signal molecules involved in regulating developmental or other processes in cnidaria, which can be isolated and their functions examined systematically with the new approach developed in this study.
The novel signal peptides, pedibin and Hym-346, lower positional value thereby enhancing foot formation in hydra.
TLDR
The results suggest that peptides play signaling roles in patterning processes in cnidaria and, plausibly, in more complex metazoans as well.
A toxin homology domain in an astacin-like metalloproteinase of the jellyfish Podocoryne carnea with a dual role in digestion and development
TLDR
Interestingly, the proteinase domain of Podocornyne PMP1 is more similar to human meprin than to HMP1 from another hydrozoan, the freshwater polyp Hydra vulgaris, which suggests a dual role of PMP 1 comparable to tolloid in development and, like astacin in the crayfish, also for food digestion.
The astacin family of metalloendopeptidases
TLDR
Meprins are unique proteases in the astacin family, and indeed in the animal kingdom, in their oligomeric structure; they are dimers of disulfide‐linked dimers and are highly glycosylated, type I integral membrane proteins that have many attributes of receptors or integrins with adhesion, epidermal growth factor‐like, and transmembrane domains.
BMP-1 and the astacin family of metalloproteinases: a potential link between the extracellular matrix, growth factors and pattern formation.
  • M. Sarras
  • Biology
    BioEssays : news and reviews in molecular, cellular and developmental biology
  • 1996
TLDR
It is found that BMP-1 is identical to pro-collagen C-proteinase, which is a metalloproteinase involved in extracellular matrix (ECM) formation, which suggests that a functional link may exist between astacin metalliproteinases, growth factors and cell differentiation and pattern formation during development.
A 25.7 x 10(3) M(r) hydra metalloproteinase (HMP1), a member of the astacin family, localizes to the extracellular matrix of Hydra vulgaris in a head-specific manner and has a developmental function.
TLDR
Hydra extracellular matrix (ECM) is composed of a number of components seen in vertebrate ECM such as laminin, type IV collagen, fibronectin, and heparan sulfate proteoglycan which indicates that hydra ECM plays an important role in pattern formation and morphogenesis of this simple metazoan.
Signal peptides: exquisitely designed transport promoters
TLDR
This review focuses on the parallels between signal peptide physical features and their functions, which emerge when the results of a variety of experimental approaches are combined.
Signaling molecules in regenerating hydra
  • B. Galliot
  • Biology
    BioEssays : news and reviews in molecular, cellular and developmental biology
  • 1997
TLDR
Modulations of the protein kinase C pathway, which have been shown to affect apical or basal positional values, might signal to bring about this polarity; however, endogenous ligands responsible for this modulation are as yet unknown.
...
1
2
3
4
...