Identification of an astacin matrix metalloprotease as target gene for Hydra foot activator peptides

@article{Kumpfmller1999IdentificationOA,
  title={Identification of an astacin matrix metalloprotease as target gene for Hydra foot activator peptides},
  author={Gaby Kumpfm{\"u}ller and Vassili Rybakine and Toshio Takahashi and Toshitaka Fujisawa and Thomas C. G. Bosch},
  journal={Development Genes and Evolution},
  year={1999},
  volume={209},
  pages={601-607}
}
Abstract Peptides serve as important signaling molecules in development and differentiation in Hydra. Two peptides, Hym-346 and pedibin, have recently been identified to act as morphogenetic signals for foot differentiation. In screening for target genes for Hym-346 we have isolated an astacin matrix metalloprotease, termed foot activator responsive matrix metalloprotease (Farm1). Farm1 is normally expressed in epithelial cells of the gastric region and absent in apical and basal tissue… 
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Hydra metalloproteinase 1 (HMP1)
Other astacin homologs
Structure, expression, and developmental function of early divergent forms of metalloproteinases in Hydra
TLDR
Functional studies indicate that these metalloproteinases play diverse and important roles in hydra morphogenesis and cell differentiation as well as specialized functions in adult polyps.
Subchapter 62B – Hym-323
Pf-ALMP, a novel astacin-like metalloproteinase with cysteine arrays, is abundant in hemocytes of pearl oyster Pinctada fucata.
Enhancement of foot formation in Hydra by a novel epitheliopeptide, Hym-323.
TLDR
Results suggest that Hym-323 is a peptide involved in a foot-patterning process in Hydra, and that the foot activation potential was increased in the peptide-treated tissue.
Control of foot differentiation in Hydra: in vitro evidence that the NK-2 homeobox factor CnNK-2 autoregulates its own expression and uses pedibin as target gene
Important roles for epithelial cell peptides in hydra development
TLDR
This review describes three peptide signaling molecules and one family of peptides that function as signaling molecules in the processes of axial pattern formation and neuron differentiation in Hydra and discusses the importance of epitheliopeptides in developmental processes within a subset of hydrozoans.
Evolution of astacin‐like metalloproteases in animals and their function in development
TLDR
It is proposed that the developmental function of most of the astacin‐like cDNAs from the marine hydroid Hydractinia echinata is not homologous to the developmentalfunction assigned to higher animals' astacins, which probably evolved after the split of the Cnidaria.
Expression of meprins in health and disease.
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