Identification of an antagonist that selectively blocks the activity of prostamides (prostaglandin‐ethanolamides) in the feline iris

  title={Identification of an antagonist that selectively blocks the activity of prostamides (prostaglandin‐ethanolamides) in the feline iris},
  author={D. Woodward and A. Krauss and J. Wang and C. Protzman and A. Nieves and Y. Liang and Y. Donde and R. M. Burk and K. Landsverk and C. Struble},
  journal={British Journal of Pharmacology},
  • D. Woodward, A. Krauss, +7 authors C. Struble
  • Published 2007
  • Chemistry, Medicine
  • British Journal of Pharmacology
  • The prostamides (prostaglandin‐ethanolamides) and prostaglandin (PG) glyceryl esters are biosynthesized by COX‐2 from the respective endocannabinoids anandamide and 2‐arachidonyl glycerol. Agonist studies suggest that their pharmacologies are unique and unrelated to prostanoid receptors. This concept was further investigated using antagonists. 
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