Identification of an ancient Bmp4 mesoderm enhancer located 46 kb from the promoter.

@article{Chandler2009IdentificationOA,
  title={Identification of an ancient Bmp4 mesoderm enhancer located 46 kb from the promoter.},
  author={Kelly J. Chandler and Ronald L. Chandler and Douglas P. Mortlock},
  journal={Developmental biology},
  year={2009},
  volume={327 2},
  pages={590-602}
}
Bone morphogenetic protein 4 (Bmp4) is a multi-functional, developmentally regulated gene that is essential for mouse development, as most Bmp4-null mouse embryos die at the onset of gastrulation and fail to develop mesoderm. Little is known about the transcriptional regulation of Bmp4. To identify potential long-range cis-regulatory elements that direct its complex spatiotemporal expression patterns, we surveyed the mouse Bmp4 locus using two overlapping bacterial artificial chromosome (BAC… CONTINUE READING

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