Identification of an aminothiazole with antifungal activity against intracellular Histoplasma capsulatum.

@article{Edwards2013IdentificationOA,
  title={Identification of an aminothiazole with antifungal activity against intracellular Histoplasma capsulatum.},
  author={Jessica A. Edwards and Megan M. Kemski and Chad A Rappleye},
  journal={Antimicrobial agents and chemotherapy},
  year={2013},
  volume={57 9},
  pages={
          4349-59
        }
}
As eukaryotes, fungi possess relatively few molecules sufficiently unique from mammalian cell components to be used as drug targets. Consequently, most current antifungals have significant host cell toxicity. Primary fungal pathogens (e.g., Histoplasma) are of particular concern, as few antifungals are effective in treating them. To identify additional antifungal candidates for the treatment of histoplasmosis, we developed a high-throughput platform for monitoring Histoplasma growth and… CONTINUE READING

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