Identification of an alternative CTLA-4 ligand costimulatory for T cell activation.

@article{Hathcock1993IdentificationOA,
  title={Identification of an alternative CTLA-4 ligand costimulatory for T cell activation.},
  author={Karen S. Hathcock and Gl{\'o}ria L{\'a}szl{\'o} and Howard B. Dickler and Jeff Bradshaw and Peter Linsley and Richard J Hodes},
  journal={Science},
  year={1993},
  volume={262 5135},
  pages={905-7}
}
Stimulation of T cell proliferation generally requires two signals: The first signal is provided by the T cell receptor binding to antigen, and the second signal or costimulus is provided by a different receptor-ligand interaction. In mouse and human, the CD28-B7 interaction has been identified as a source of costimulatory signals. We have identified a cell surface molecule (GL1) that is distinct from B7 and abundantly expressed on activated B cells. On activated B cells GL1, rather than B7, is… CONTINUE READING
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