Identification of an alternative CTLA-4 ligand costimulatory for T cell activation.

  title={Identification of an alternative CTLA-4 ligand costimulatory for T cell activation.},
  author={Karen S. Hathcock and Gl{\'o}ria L{\'a}szl{\'o} and Howard B. Dickler and Jeff Bradshaw and Peter Linsley and Richard J Hodes},
  volume={262 5135},
Stimulation of T cell proliferation generally requires two signals: The first signal is provided by the T cell receptor binding to antigen, and the second signal or costimulus is provided by a different receptor-ligand interaction. In mouse and human, the CD28-B7 interaction has been identified as a source of costimulatory signals. We have identified a cell surface molecule (GL1) that is distinct from B7 and abundantly expressed on activated B cells. On activated B cells GL1, rather than B7, is… CONTINUE READING
Highly Influential
This paper has highly influenced 12 other papers. REVIEW HIGHLY INFLUENTIAL CITATIONS

From This Paper

Topics from this paper.


Publications citing this paper.
Showing 1-10 of 125 extracted citations

The potential for antitumor vaccination in acute myelogenous leukemia

Journal of Molecular Medicine • 1998
View 12 Excerpts
Highly Influenced

Similar Papers

Loading similar papers…