Identification of an agonist ligand for estrogen-related receptors ERRbeta/gamma.

  title={Identification of an agonist ligand for estrogen-related receptors ERRbeta/gamma.},
  author={Donna D Yu and Barry Marc Forman},
  journal={Bioorganic & medicinal chemistry letters},
  volume={15 5},
In order to develop agonist ligands that are specific for the estrogen-related receptors ERRbeta/gamma, a hydrazone with a 4-hydroxy group at one phenyl ring and a 4-diethylamino moiety at the other phenyl ring was synthesized. We demonstrate that compound 3 (DY131; N'-{(1E)-[4-(diethylamino)phenyl]methylene}-4-hydroxybenzohydrazide) effectively and selectively activates ERRbeta/gamma. DY131 had no effect on the structurally related receptors ERRalpha or the estrogen receptors alpha and beta… CONTINUE READING

From This Paper

Topics from this paper.


Publications citing this paper.
Showing 1-10 of 25 extracted citations

Similar Papers

Loading similar papers…