Identification of an agonist ligand for estrogen-related receptors ERRbeta/gamma.

@article{Yu2005IdentificationOA,
  title={Identification of an agonist ligand for estrogen-related receptors ERRbeta/gamma.},
  author={Donna D Yu and Barry Marc Forman},
  journal={Bioorganic & medicinal chemistry letters},
  year={2005},
  volume={15 5},
  pages={1311-3}
}
In order to develop agonist ligands that are specific for the estrogen-related receptors ERRbeta/gamma, a hydrazone with a 4-hydroxy group at one phenyl ring and a 4-diethylamino moiety at the other phenyl ring was synthesized. We demonstrate that compound 3 (DY131; N'-{(1E)-[4-(diethylamino)phenyl]methylene}-4-hydroxybenzohydrazide) effectively and selectively activates ERRbeta/gamma. DY131 had no effect on the structurally related receptors ERRalpha or the estrogen receptors alpha and beta… CONTINUE READING

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