Identification of an aflatoxin G1-serum albumin adduct and its relevance to the measurement of human exposure to aflatoxins.

@article{Sabbioni1991IdentificationOA,
  title={Identification of an aflatoxin G1-serum albumin adduct and its relevance to the measurement of human exposure to aflatoxins.},
  author={Gabriele Sabbioni and Christopher Paul Wild},
  journal={Carcinogenesis},
  year={1991},
  volume={12 1},
  pages={
          97-103
        }
}
A major aflatoxin G1 (AFG1)-albumin adduct has been identified and characterized in rats following exposure to AFG1. The product isolated from a Pronase digest of in vivo-modified albumin was identical by chromatographic retention time to the synthetic product obtained by the acylase-catalysed deacetylation product of N alpha-acetyl-L-lysine with 8,9-dihydro-8,9-dibromo-AFG1. The in vitro product, AFG1-lysine, was characterized by UV, fluorescence, 1H- and 13C-NMR spectroscopy and fast atom… CONTINUE READING

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