Identification of an adipogenic niche for adipose tissue remodeling and restoration.

@article{Lee2013IdentificationOA,
  title={Identification of an adipogenic niche for adipose tissue remodeling and restoration.},
  author={Yun-Hee Lee and Anelia P. Petkova and James Gerard Granneman},
  journal={Cell metabolism},
  year={2013},
  volume={18 3},
  pages={
          355-67
        }
}
The regulatory events guiding progenitor activation and differentiation in adult white adipose tissue are largely unknown. We report that induction of brown adipogenesis by β3-adrenergic receptor (ADRB3) activation involves the death of white adipocytes and their removal by M2-polarized macrophages. Recruited macrophages express high levels of osteopontin (OPN), which attracts a subpopulation of PDGFRα+ progenitors expressing CD44, a receptor for OPN. Preadipocyte proliferation is highly… CONTINUE READING
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