Identification of an additional supraspinal component to the analgesic mechanism of action of buprenorphine.

@article{Ding2009IdentificationOA,
  title={Identification of an additional supraspinal component to the analgesic mechanism of action of buprenorphine.},
  author={Zhe Ding and Robert B Raffa},
  journal={British journal of pharmacology},
  year={2009},
  volume={157 5},
  pages={831-43}
}
BACKGROUND AND PURPOSE Buprenorphine displays attributes of opioids, but also some features distinct from them. We examined spinal and supraspinal signal transduction of buprenorphine-induced anti-nociception in mice compared with morphine and fentanyl. EXPERIMENTAL APPROACH The opioid receptor antagonist naloxone, Pertussis toxin (PTX), G(z) protein antisense and nociceptin/orphanin-FQ receptor agonist nociceptin, and antagonist, JTC-801, were injected supraspinally (intracerebroventricular… CONTINUE READING
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