Identification of an Outer Segment Targeting Signal in the Cooh Terminus of Rhodopsin Using Transgenic Xenopus laevis

@article{Tam2000IdentificationOA,
  title={Identification of an Outer Segment Targeting Signal in the Cooh Terminus of Rhodopsin Using Transgenic Xenopus laevis},
  author={Beatrice M. Tam and Orson L. Moritz and Lawrence B. Hurd and David S. Papermaster},
  journal={The Journal of Cell Biology},
  year={2000},
  volume={151},
  pages={1369 - 1380}
}
Mislocalization of the photopigment rhodopsin may be involved in the pathology of certain inherited retinal degenerative diseases. Here, we have elucidated rhodopsin's targeting signal which is responsible for its polarized distribution to the rod outer segment (ROS). Various green fluorescent protein (GFP)/rhodopsin COOH-terminal fusion proteins were expressed specifically in the major red rod photoreceptors of transgenic Xenopus laevis under the control of the Xenopus opsin promoter. The… CONTINUE READING
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