Identification of an NTF2-related factor that binds Ran-GTP and regulates nuclear protein export.

@article{Black1999IdentificationOA,
  title={Identification of an NTF2-related factor that binds Ran-GTP and regulates nuclear protein export.},
  author={Ben E. Black and Lyne L{\'e}vesque and James M Holaska and Thomas Charles Wood and Bryce M. Paschal},
  journal={Molecular and cellular biology},
  year={1999},
  volume={19 12},
  pages={8616-24}
}
Active transport of macromolecules between the nucleus and cytoplasm requires signals for import and export and their recognition by shuttling receptors. Each class of macromolecule is thought to have a distinct receptor that mediates the transport reaction. Assembly and disassembly reactions of receptor-substrate complexes are coordinated by Ran, a GTP-binding protein whose nucleotide state is regulated catalytically by effector proteins. Ran function is modulated in a noncatalytic fashion by… CONTINUE READING
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