Identification of an NADH plus iron dependent, Ca2+ activated hydrogen peroxide production in synaptosomes.

Abstract

The addition of microM Ca2+ to synaptosomes incubated in the presence of EGTA and NADH activates a slow production of H2O2, which is promptly inhibited by excess EGTA and reactivated by Ca2+. The H2O2 output is inhibited by the Fe chelator deferoxamine. Higher Ca(2+)-dependent H2O2 productions are induced in the presence of added FeCl3 in the absence of… (More)

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