Identification of an HLA-A2-Restricted Epitope Peptide Derived from Hypoxia-Inducible Protein 2 (HIG2)

@inproceedings{Yoshimura2014IdentificationOA,
  title={Identification of an HLA-A2-Restricted Epitope Peptide Derived from Hypoxia-Inducible Protein 2 (HIG2)},
  author={Sachiko Yoshimura and Takuya Tsunoda and Ryuji Osawa and Makiko Harada and Tomohisa Watanabe and Tetsuro Hikichi and Masahiro Katsuda and Motoki Miyazawa and Masaji Tani and Makoto Iwahashi and Kazuyoshi Takeda and Toyomasa Katagiri and Yusuke Nakamura and Hiroki Yamaue},
  booktitle={PloS one},
  year={2014}
}
We herein report the identification of an HLA-A2 supertype-restricted epitope peptide derived from hypoxia-inducible protein 2 (HIG2), which is known to be a diagnostic marker and a potential therapeutic target for renal cell carcinoma. Among several candidate peptides predicted by the HLA-binding prediction algorithm, HIG2-9-4 peptide (VLNLYLLGV) was able to effectively induce peptide-specific cytotoxic T lymphocytes (CTLs). The established HIG2-9-4 peptide-specific CTL clone produced… CONTINUE READING

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