Identification of an Endogenous Ligand Bound to a Native Orphan Nuclear Receptor

Abstract

Orphan nuclear receptors have been instrumental in identifying novel signaling pathways and therapeutic targets. However, identification of ligands for these receptors has often been based on random compound screens or other biased approaches. As a result, it remains unclear in many cases if the reported ligands are the true endogenous ligands,--i.e., the… (More)
DOI: 10.1371/journal.pone.0005609

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Cite this paper

@article{Yuan2009IdentificationOA, title={Identification of an Endogenous Ligand Bound to a Native Orphan Nuclear Receptor}, author={Xiaohui Yuan and Tuong Chi Ta and Min Lin and Jane R. Evans and Yinchen Dong and Eugene Bolotin and Mark Andrew Sherman and Barry Marc Forman and Frances M. Sladek}, journal={PLoS ONE}, year={2009}, volume={4}, pages={789 - 799} }