Identification of an Atlantic salmon IFN multigene cluster encoding three IFN subtypes with very different expression properties.

@article{Sun2009IdentificationOA,
  title={Identification of an Atlantic salmon IFN multigene cluster encoding three IFN subtypes with very different expression properties.},
  author={Baojian Sun and B\orre Robertsen and Zhiqiang Wang and Bin Liu},
  journal={Developmental and comparative immunology},
  year={2009},
  volume={33 4},
  pages={547-58}
}
A cluster of 11 interferon (IFN) genes were identified in the Atlantic salmon genome linked to the growth hormone 1 gene. The genes encode three different IFN subtypes; IFNa (two genes), IFNb (four genes) and IFNc (five genes), which show 22-32% amino acid sequence identity. Expression of the fish IFNs were studied in head kidney, leukocytes or TO cells after stimulation with the dsRNA poly I:C or the imidazoquinoline S-27609. In mammals, poly I:C induces IFN-beta through the RIG-I/MDA5 or the… CONTINUE READING