Identification of amyloidogenic light chains requires the combination of serum-free light chain assay with immunofixation of serum and urine.

@article{Palladini2009IdentificationOA,
  title={Identification of amyloidogenic light chains requires the combination of serum-free light chain assay with immunofixation of serum and urine.},
  author={Giovanni Palladini and Paola Russo and Tiziana Bosoni and Laura Verga and Gabriele Sarais and Francesca Lavatelli and Mario Nuvolone and Laura Obici and Simona Casarini and Simona Donadei and Riccardo Albertini and Gabriella Righetti and Maddalena Marini and Maria Stella Graziani and Gian Vico Melzi d'Eril and Remigio Moratti and Giampaolo Merlini},
  journal={Clinical chemistry},
  year={2009},
  volume={55 3},
  pages={
          499-504
        }
}
BACKGROUND The diagnosis of systemic immunoglobulin light-chain (AL) amyloidosis requires demonstration of amyloid deposits in a tissue biopsy and amyloidogenic monoclonal light chains. The optimal strategy to identify the amyloidogenic clone has not been established. We prospectively assessed the diagnostic sensitivity of the serum free light chain (FLC) kappa/lambda ratio, a commercial serum and urine agarose gel electrophoresis immunofixation (IFE), and the high-resolution agarose gel… CONTINUE READING
Highly Cited
This paper has 69 citations. REVIEW CITATIONS

Citations

Publications citing this paper.
Showing 1-10 of 73 citations

70 Citations

051015'10'12'14'16'18
Citations per Year
Semantic Scholar estimates that this publication has 70 citations based on the available data.

See our FAQ for additional information.

References

Publications referenced by this paper.
Showing 1-10 of 20 references