Identification of amyloid-beta 1-42 binding protein fragments by screening of a human brain cDNA library.

@article{Mungua2006IdentificationOA,
  title={Identification of amyloid-beta 1-42 binding protein fragments by screening of a human brain cDNA library.},
  author={Mar{\'i}a Elena Mungu{\'i}a and Tzipe Govezensky and Rodrigo Martinez and Karen Manoutcharian and Goar Gevorkian},
  journal={Neuroscience letters},
  year={2006},
  volume={397 1-2},
  pages={79-82}
}
Extracellular and intraneuronal formation of amyloid-beta (Abeta) deposits have been demonstrated to be involved in the pathogenesis of Alzheimer's disease (AD). However, the precise mechanism of Abeta neurotoxicity is not completely understood. Previous studies suggest that binding of Abeta with a number of targets have deleterious effects on cellular functions. It has been shown that Abeta directly interacted with intracellular protein ERAB (endoplasmic reticulum amyloid beta-peptide-binding… CONTINUE READING

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