Identification of amino acids involved in the binding of hMIP-1α to CC-CKR1, a MIP-lα receptor found on neutrophils

@article{Crisman2004IdentificationOA,
  title={Identification of amino acids involved in the binding of hMIP-1α to CC-CKR1, a MIP-lα receptor found on neutrophils},
  author={Jacqueline M. Crisman and Patrick J. Elder and Neil M. Wilkie and Pappachan E. Kolattukudy},
  journal={Molecular and Cellular Biochemistry},
  year={2004},
  volume={195},
  pages={245-256}
}
Human macrophage inflammatory protein-1α (hMIP-1α) and human macrophage inflammatory protein-1β (hMIP-1β) are chemokines involved in a diverse range of immunological effects. Both hMIP-1α and hMIP-1β are involved in the activation of monocytes and THP-1 cells probably through a common receptor(s). However, only hMIP-1α can bind to neutrophils with high affinity, presumably through CC-CKR1 (CKR1). Since the structure of these two proteins is highly conserved, non-conserved amino acids must… CONTINUE READING