Identification of amino acids in the hormone binding domain of the human estrogen receptor important in estrogen binding.

@article{Ekena1996IdentificationOA,
  title={Identification of amino acids in the hormone binding domain of the human estrogen receptor important in estrogen binding.},
  author={Kirk Ekena and Karen E Weis and John A. Katzenellenbogen and Benita S Katzenellenbogen},
  journal={The Journal of biological chemistry},
  year={1996},
  volume={271 33},
  pages={20053-9}
}
The initial step in the regulation of the transcriptional activity of the estrogen receptor (ER) is the binding of hormone. Previous studies have suggested that the region between amino acids 515 and 535 near the C terminus of the human ER is likely to be important in ligand binding. In order to explicitly define which amino acids in this region are critical for ligand recognition and binding, we have utilized alanine-scanning mutagenesis over the complete 515-535 region. The ability of these… CONTINUE READING

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