Identification of amino acids in the dengue virus type 2 envelope glycoprotein critical to virus infectivity.

@article{Kroschewski2009IdentificationOA,
  title={Identification of amino acids in the dengue virus type 2 envelope glycoprotein critical to virus infectivity.},
  author={Helga Kroschewski and Jos{\'e}-Luis Sagripanti and Andrew D. Davidson},
  journal={The Journal of general virology},
  year={2009},
  volume={90 Pt 10},
  pages={2457-61}
}
The dengue virus envelope glycoprotein mediates virus attachment and entry and is the major viral antigen. The identification of 'critical' amino acids in the envelope glycoprotein that cannot be altered without loss of infectivity could have a major impact on the development of dengue virus vaccines and diagnostics. In this context, we determined whether six amino acids, previously predicted by computational analysis to play a critical role in the virus life cycle, were essential for virus… CONTINUE READING

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