Identification of amino acid residues of Salmonella SlyA that are critical for transcriptional regulation.

@article{Okada2007IdentificationOA,
  title={Identification of amino acid residues of Salmonella SlyA that are critical for transcriptional regulation.},
  author={Nobuhiko Okada and Yorie Oi and Mayuko Takeda-Shitaka and Kazuhiko Kanou and Hideaki Umeyama and Takeshi Haneda and Tsuyoshi Miki and Sachiko Hosoya and Hirofumi Danbara},
  journal={Microbiology},
  year={2007},
  volume={153 Pt 2},
  pages={548-60}
}
The type III secretion system encoded by Salmonella pathogenicity island 2 (SPI-2) is essential for the intracellular survival and replication of Salmonella enterica. The expression of SPI-2 genes is dependent on a two-component regulatory system, SsrA (SpiR)/SsrB, encoded in the SPI-2 region. This paper shows that SlyA regulates transcription of the sensor kinase SsrA by binding to the ssrA promoter, indicating that SlyA is directly involved in the regulation of SPI-2 gene expression. A… CONTINUE READING

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