Identification of amino acid residues in HIV-1 reverse transcriptase that are critical for the proteolytic processing of Gag-Pol precursors.

Abstract

The efficient processing of human immunodeficiency virus type 1 Gag-Pol requires not only protease activity but also specific reverse transcriptase (RT) and integrase sequences. However, the critical amino acid residues of the HIV-1 Pol gene involved in protease-mediated Gag-Pol processing have not been precisely defined. Here, we found that the… (More)
DOI: 10.1016/j.febslet.2011.09.034

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@article{Nishitsuji2011IdentificationOA, title={Identification of amino acid residues in HIV-1 reverse transcriptase that are critical for the proteolytic processing of Gag-Pol precursors.}, author={Hironori Nishitsuji and Masaru Yokoyama and Hironori Sato and Suguru Yamauchi and Hiroshi Takaku}, journal={FEBS letters}, year={2011}, volume={585 21}, pages={3372-7} }