Identification of amino acid residues in BK virus VP1 that are critical for viability and growth.

@article{Dugan2007IdentificationOA,
  title={Identification of amino acid residues in BK virus VP1 that are critical for viability and growth.},
  author={Aisling S. Dugan and Megan L Gasparovic and Natia Tsomaia and Dale F. Mierke and Bethany A O'hara and Kate Manley and Walter J Atwood},
  journal={Journal of virology},
  year={2007},
  volume={81 21},
  pages={11798-808}
}
BK virus (BKV) is a ubiquitous pathogen that establishes a persistent infection in the urinary tract of 80% of the human population. Like other polyomaviruses, the major capsid protein of BKV, virion protein 1 (VP1), is critical for host cell receptor recognition and for proper virion assembly. BKV uses a carbohydrate complex containing alpha(2,3)-linked sialic acid attached to glycoprotein and glycolipid motifs as a cellular receptor. To determine the amino acids important for BKV binding to… CONTINUE READING

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