Identification of alternatively spliced messenger ribonucleic acid encoding truncated growth hormone-releasing hormone receptor in human pituitary adenomas.

@article{Hashimoto1995IdentificationOA,
  title={Identification of alternatively spliced messenger ribonucleic acid encoding truncated growth hormone-releasing hormone receptor in human pituitary adenomas.},
  author={Kazuhiko Hashimoto and Makoto Koga and Tomotaka Motomura and Soji Kasayama and Haruhiko Kouhara and Takeo Ohnishi and Norio Arita and Tohru Hayakawa and Bunzo Sato and Toshimitsu Kishimoto},
  journal={The Journal of clinical endocrinology and metabolism},
  year={1995},
  volume={80 10},
  pages={
          2933-9
        }
}
The expression of GHRH receptor (GHRH-R) messenger ribonucleic acid (mRNA) was studied in 22 pituitary adenomas and 2 normal anterior pituitaries. Northern blot analysis revealed that GHRH-R mRNA were expressed in all 14 GH-producing adenomas, 1 of 3 ACTH-producing adenomas, the 1 PRL-producing adenoma, 2 of 4 nonfunctioning adenomas, and the 2 normal anterior pituitaries. Their expression levels varied among GH-producing adenomas and were relatively low in GH-nonproducing adenomas. In addition… CONTINUE READING
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