Identification of alternatively activated macrophages in new-onset paediatric and adult immunoglobulin A nephropathy: potential role in mesangial matrix expansion.

@article{Ikezumi2011IdentificationOA,
  title={Identification of alternatively activated macrophages in new-onset paediatric and adult immunoglobulin A nephropathy: potential role in mesangial matrix expansion.},
  author={Yohei Ikezumi and Toshiaki Suzuki and Tamaki Karasawa and Hiroya Hasegawa and Takeshi Yamada and Naofumi Imai and Ichiei Narita and Hiroshi Kawachi and Kevan Roy Polkinghorne and David J Nikolic-Paterson and Makoto Uchiyama},
  journal={Histopathology},
  year={2011},
  volume={58 2},
  pages={198-210}
}
AIMS New onset of the clinical symptoms of immunoglobulin A (IgA) nephropathy (IgAN) manifests with proliferative glomerular lesions in children, whereas adults exhibit mesangial matrix expansion and interstitial fibrosis. Alternatively, activated (M2) macrophages have been implicated in promoting tissue fibrosis in some settings. Therefore, the aim of this study was to investigate whether M2 macrophages are present in new-onset IgAN and if they are related to pathological differences between… CONTINUE READING