Identification of alternative splicing markers for breast cancer.

  title={Identification of alternative splicing markers for breast cancer.},
  author={Julian P. Venables and Roscoe Klinck and Anne Bramard and Lyna Inkel and Genevi{\`e}ve Dufresne-Martin and Chushin Koh and Julien Gervais-Bird and Elvy Lapointe and Ulrike Froehlich and Mathieu Durand and Daniel Gendron and Jean-Philippe Brosseau and Philippe Thibault and Jean-François Lucier and Karine Tremblay and Panagiotis Prinos and Raymund J Wellinger and Benoit Chabot and Claudine Rancourt and Sherif Abou Elela},
  journal={Cancer research},
  volume={68 22},
Breast cancer is the most common cause of cancer death among women under age 50 years, so it is imperative to identify molecular markers to improve diagnosis and prognosis of this disease. Here, we present a new approach for the identification of breast cancer markers that does not measure gene expression but instead uses the ratio of alternatively spliced mRNAs as its indicator. Using a high-throughput reverse transcription-PCR-based system for splicing annotation, we monitored the alternative… CONTINUE READING