Identification of alpha-fodrin as a candidate autoantigen in primary Sjögren's syndrome.


It is unclear whether organ-specific autoantigens are critical for the development of primary Sjögren's syndrome (SS). A 120-kilodalton organ-specific autoantigen was purified from salivary gland tissues of an NFS/sld mouse model of human SS. The amino-terminal residues were identical to those of the human cytoskeletal protein alpha-fodrin. The purified antigen induced proliferative T cell responses and production of interleukin-2 and interferon-gamma in vitro. Neonatal immunization with the 120-kilodalton antigen prevented the disease in mice. Sera from patients with SS reacted positively with purified antigen and recombinant human alpha-fodrin protein, whereas those from patients with systemic lupus erythematosus and rheumatoid arthritis did not. Thus, the immune response to 120-kilodalton alpha-fodrin could be important in the initial development of primary SS.

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@article{Haneji1997IdentificationOA, title={Identification of alpha-fodrin as a candidate autoantigen in primary Sj{\"{o}gren's syndrome.}, author={N. Haneji and Tadashi Nakamura and Kenji Takio and Kazuo Yanagi and Hiroyuki Higashiyama and Isao Saito and Sumihare Noji and Hiromu Sugino and Yuichiro Hayashi}, journal={Science}, year={1997}, volume={276 5312}, pages={604-7} }