Identification of alpha-dicarbonyl scavengers for cellular protection against carbonyl stress.

@article{Wondrak2002IdentificationOA,
  title={Identification of alpha-dicarbonyl scavengers for cellular protection against carbonyl stress.},
  author={Georg Thomas Wondrak and Daniel Cervantes-Laurean and Michael J. Roberts and Jaber G. Qasem and Moonsun Kim and Elaine L. Jacobson and Myron K. Jacobson},
  journal={Biochemical pharmacology},
  year={2002},
  volume={63 3},
  pages={361-73}
}
Tissue deterioration and aging have long been associated with the accumulation of chemically induced protein and DNA damage. Reactive oxygen species (ROS) and reactive carbonyl species (RCS), especially alpha-dicarbonyl compounds, are key mediators of damage caused by oxidative stress, glycation, and UV-irradiation. The toxic effects of ROS are counteracted in vivo by antioxidants and antioxidant enzymes, and the deleterious effects of one RCS, methylglyoxal, are counteracted by a ubiquitous… CONTINUE READING
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