Identification of alpha- and beta-cardiac myosin heavy chain isoforms as major autoantigens in dilated cardiomyopathy.

@article{Caforio1992IdentificationOA,
  title={Identification of alpha- and beta-cardiac myosin heavy chain isoforms as major autoantigens in dilated cardiomyopathy.},
  author={Alida Linda Caforio and Michele Grazzini and Jessica M. Mann and Philip J. Keeling and Gian Franco Bottazzo and William J. McKenna and Stefano Schiaffino},
  journal={Circulation},
  year={1992},
  volume={85 5},
  pages={1734-42}
}
BACKGROUND Immunization with cardiac myosin induces experimental autoimmune heart disease in genetically predisposed mice. These mice produce heart-specific autoantibodies, some of which are directed against the cardiac myosin isoform. METHODS AND RESULTS We have reported the presence of circulating heart-specific autoantibodies in 26% of patients with idiopathic dilated cardiomyopathy (DCM) using indirect immunofluorescence. To identify the autoantigen(s) recognized by heart-specific… CONTINUE READING

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